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A-485

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

Outcomes

2

Postmenopausal osteoporosis

downin rats1

1 study

  1. A-485 protects against postmenopausal osteoporosis in rats.

    “A-485 ameliorates postmenopausal OP by activating GLUD1 deacetylation via the SENP1-Sirt3 signal pathway”

    Animalsin ovariectomized ratsintraperitoneal injection100 mg/kg/day6 weeksfemalesn = 61

    A-485 alleviates postmenopausal osteoporosis by activating GLUD1 deacetylation through the SENP1-Sirt3 signal pathway

    Journal of orthopaedic surgery and research29 May 2025

More on Postmenopausal osteoporosis

Bone mineral density

upin rats1

1 study

  1. A-485 increases bone mineral density in rats.

    “In vivo, ovariectomized rats exhibited lower BMD, impaired bone trabeculae, increased CTX-1 and DPD, and altered expression of Runx2 and OCN, all of which were reversed by A-485 treatment.”

    Animalsin ovariectomized ratsintraperitoneal injection100 mg/kg/day6 weeksfemalesn = 61

    A-485 alleviates postmenopausal osteoporosis by activating GLUD1 deacetylation through the SENP1-Sirt3 signal pathway

    Journal of orthopaedic surgery and research29 May 2025

More on Bone mineral density

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