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8-br-cgmp

Intervention

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 1 more
  • Animals1

Outcomes

1

Cellular senescence

downin human cells1

1 study

  1. 8-br-cgmp decreases cellular senescence in human cells.

    “8-Br-cGMP (analog of cGMP), or AICAR (AMPK activator), counteracted the observed changes in HUVECs.”

    Cellsin HUVECs with NPRA suppression

    Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure

    Aging cell

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