6-gingerol
6-gingerol has been studied in 4 papers since 2016: none in people yet, 3 in animals, 1 review. The research so far is in animals. The newest paper, Jun 26, 2025: “Deciphering the Antiaging Effective Components in the Geo-authentic Tibetan Medicine Brassica rapa L. Based on the "Environment-Food-Human" Web”.
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Korea Institute for Advancement of Technology and 1 more
- 6 of 9 findings with company ties
- Animals1
- Model organisms2
What did studies of 6-gingerol find?
9Studies of 6-gingerol measured 9 outcomes; the most studied are AMPK signaling (1 study), inflammation (1) and insulin resistance (1).
AMPK signaling
upin rats1
1 study
AMPK signaling
upin rats1
6-gingerol activates AMPK signaling in rats.
“elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473)”
Animalsgavageepididymal white adipose tissue0.2 mg·kg~(-1)seven weeksmalesn = 9
6-Gingerol ameliorates adipose tissue insulin resistance in aging rats
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Inflammation
downin rats1
1 study
Inflammation
downin rats1
6-gingerol decreases inflammation in rats.
“reduced the protein and mRNA expression of TNF-α, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.”
Animalsgavageepididymal white adipose tissue0.2 mg·kg~(-1)seven weeksmalesn = 9
6-Gingerol ameliorates adipose tissue insulin resistance in aging rats
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Insulin resistance
downin rats1
1 study
Insulin resistance
downin rats1
6-gingerol decreases insulin resistance in rats.
“6-gingerol at a high dose could significantly decrease the fasting plasma content of NEFA and insulin and reduce Adipo-IR.”
Animalsgavageadipose tissue0.2 mg·kg~(-1)seven weeksmalesn = 9
6-Gingerol ameliorates adipose tissue insulin resistance in aging rats
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Movement
no changein worms1
1 study
Movement
no changein worms1
6-gingerol has no effect on movement in worms.
“No significant 6-gingerol-related changes, including growth, food intake, reproduction, and movement were noted.”
Model organisms
Biomolecules & therapeutics
Lipofuscin
downin worms1
1 study
Lipofuscin
downin worms1
6-gingerol decreases lipofuscin in worms.
“The lipofuscin levels in 6-gingerol treated intestinal worms were decreased in comparison to the control group.”
Model organismscompared with control groupintestine
Biomolecules & therapeutics
Antioxidant enzyme activity
upin worms1
1 study
Antioxidant enzyme activity
upin worms1
6-gingerol increases antioxidant enzyme activity in worms.
“Additionally, 6-gingerol elevated the antioxidant enzyme activities of C. elegans”
Model organisms
Biomolecules & therapeutics
Intracellular reactive oxygen species
downin worms1
1 study
Intracellular reactive oxygen species
downin worms1
6-gingerol decreases intracellular reactive oxygen species in worms.
“showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms.”
Model organisms
Biomolecules & therapeutics
Survival under thermal, osmotic, and oxidative stress
upin worms1
1 study
Survival under thermal, osmotic, and oxidative stress
upin worms1
6-gingerol increases survival under thermal, osmotic, and oxidative stress in worms.
“It also elevated the survival rate of worms against stressful environment including thermal, osmotic, and oxidative conditions.”
Model organismsthermal, osmotic, and oxidative conditions
Biomolecules & therapeutics
Lifespan
upin worms1
1 study
Lifespan
upin worms1
6-gingerol extends lifespan in worms.
“The compound 6-gingerol was isolated from the most active ethyl acetate soluble fraction, and showed potent longevity-promoting activity.”
Model organisms
Biomolecules & therapeutics