2-o-methylmagnolol

1. 2-o-methylmagnolol has no effect on cell proliferation in human cells.

   “Treatment with 2-MG at concentrations up to 10 μM did not significantly affect HGEs and HGFs cell proliferation (P > 0.05)”

   Cellsup to 10 μM

   2-O-methylmagnolol mitigates the generation of reactive oxidative stress and inflammaging in human gingival epithelial cells and fibroblasts with advanced glycation end products stimulation

   Journal of dental sciences·21 May 2025

1. 2-o-methylmagnolol inhibits cellular senescence in human cells.

   “2-MG reduced cellular senescence and suppressed the secretion of IL-6 and IL-8 (P < 0.05)”

   CellsAGEs stimulation

   2-O-methylmagnolol mitigates the generation of reactive oxidative stress and inflammaging in human gingival epithelial cells and fibroblasts with advanced glycation end products stimulation

   Journal of dental sciences·21 May 2025

More on Cellular senescence

1. 2-o-methylmagnolol improves wound healing in human cells.

   “2-MG effectively improved AGEs-induced wound healing impairment”

   CellsAGEs-induced wound healing impairment

   2-O-methylmagnolol mitigates the generation of reactive oxidative stress and inflammaging in human gingival epithelial cells and fibroblasts with advanced glycation end products stimulation

   Journal of dental sciences·21 May 2025

1. 2-o-methylmagnolol inhibits oxidative stress and ROS signalling in human cells.

   “significantly attenuated ROS production in a dose-dependent manner (P < 0.05)”

   CellsAGEs stimulation

   2-O-methylmagnolol mitigates the generation of reactive oxidative stress and inflammaging in human gingival epithelial cells and fibroblasts with advanced glycation end products stimulation

   Journal of dental sciences·21 May 2025

More on Oxidative stress and ROS signalling