2-(3-mercaptopropyl)pentanedioic acid

1 paper2 findings

PubChem 10198171

Animals1

Outcomes

2

Tau phosphorylated at Thr217

downin rhesus monkeys1

1 study

2-(3-mercaptopropyl)pentanedioic acid decreases tau phosphorylated at Thr217 in rhesus monkeys.
“chronic inhibition of GCPII with the orally bioavailable inhibitor 2-(3-mercaptopropyl) pentanedioic acid (2-MPPA) improved neuronal firing, working memory, and reduced pT217Tau pathology in aged macaques.”
Reviewchronic treatment
Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease
bioRxiv : the preprint server for biology10 Nov 2025Preprint

More on Tau phosphorylated at Thr217

Working memory

upin rhesus monkeys1

1 study

2-(3-mercaptopropyl)pentanedioic acid improves working memory in rhesus monkeys.
“chronic inhibition of GCPII with the orally bioavailable inhibitor 2-(3-mercaptopropyl) pentanedioic acid (2-MPPA) improved neuronal firing, working memory, and reduced pT217Tau pathology in aged macaques.”
Reviewchronic treatment
Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease
bioRxiv : the preprint server for biology10 Nov 2025Preprint

Latest

1 in 12 months

bioRxiv26 Nov

Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease

Preprint: experiments in monkeysAlzheimer's disease