Tau phosphorylated at Thr217

1 paper1 finding

Animals1

Interventions

1

2-(3-mercaptopropyl)pentanedioic acid

downin rhesus monkeys1

1 study

2-(3-mercaptopropyl)pentanedioic acid decreases tau phosphorylated at Thr217 in rhesus monkeys.
“chronic inhibition of GCPII with the orally bioavailable inhibitor 2-(3-mercaptopropyl) pentanedioic acid (2-MPPA) improved neuronal firing, working memory, and reduced pT217Tau pathology in aged macaques.”
Reviewchronic treatment
Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease
bioRxiv : the preprint server for biology10 Nov 2025Preprint

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