YCA1
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: National Key R&D Program of China and 5 more
- Cells2
Effects
2Lifespan
downin yeast cells1
1 study
Lifespan
downin yeast cells1
YCA1 shortens lifespan in yeast cells.
“increased YCA1 activity led to reduced chronological lifespan (CLS)”
Cellsin BY4742 Δcys3 mutant with increased YCA1 activity
Antioxidants (Basel, Switzerland)
Oxidative stress and ROS signaling
upin yeast cells1
1 study
Oxidative stress and ROS signaling
upin yeast cells1
YCA1 increases oxidative stress and ROS signaling in yeast cells.
“When deleting YCA1, the caspase-like activity and the oxidative stress decreased”
CellsShown by YCA1 deletion in the PUFA-producing strain
FEMS yeast research
Upstream
2CYS3
downin yeast cells1
1 study
CYS3
downin yeast cells1
CYS3 inhibits YCA1 in yeast cells.
“The activity of YCA1 was significantly increased by the deletion of CYS3.”
Cellsshown by CYS3 knockout mutant BY4742 Δcys3
Antioxidants (Basel, Switzerland)
Reactive sulfane sulfur
downin yeast cells1
1 study
Reactive sulfane sulfur
downin yeast cells1
Reactive sulfane sulfur inhibits YCA1 in yeast cells.
“reactive sulfane sulfur (RSS) can inhibit the activity of YCA1.”
Cellsin vitro
Antioxidants (Basel, Switzerland)
Latest
FEMS Yeast Research
PUFA-induced cell death is mediated by Yca1p-dependent and -independent pathways, and is reduced by vitamin C in yeast
Experiments in yeastMechanisms