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VPS27

Gene

1 paper2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Centre National de la Recherche Scientifique and 8 more
  • Cells1

Effects

2

Mitochondrial respiration

is required forin yeast cells1

1 study

  1. VPS27 is required for mitochondrial respiration in yeast cells.

    “Vps27 was critical for iron homeostasis and mitochondrial function in sit4∆ cells, as sit4∆vps27∆ double mutants exhibited high iron levels and impaired mitochondrial respiration.”

    CellsSIT4-deleted cells; shown by additional VPS27 deletion

    Sit4 Genetically Interacts with Vps27 to Regulate Mitochondrial Function and Lifespan in Saccharomyces cerevisiae

    Cells9 Apr 2024

Iron

downin yeast cells1

1 study

  1. VPS27 decreases iron in yeast cells.

    “Vps27 was critical for iron homeostasis and mitochondrial function in sit4∆ cells, as sit4∆vps27∆ double mutants exhibited high iron levels and impaired mitochondrial respiration.”

    CellsSIT4-deleted cells; shown by additional VPS27 deletion

    Sit4 Genetically Interacts with Vps27 to Regulate Mitochondrial Function and Lifespan in Saccharomyces cerevisiae

    Cells9 Apr 2024

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