VCL
- 1 lab in 1 country
- Humans2
- Animals5
- Model organisms2
- Cells1
Effects
1Cardiac aging
downin A. gambiae1
1 study
Cardiac aging
downin A. gambiae1
VCL protects against cardiac aging in A. gambiae.
“RNAi-based knockdown of MnSOD1 or vinculin resulted in heart physiology that trended toward the aging phenotype for every parameter that was measured”
Model organismsRNAi knockdownheartfemales
Mosquito aging modulates the heart rate and the proportional directionality of heart contractions
Journal of insect physiology
Latest
1 paper in 12 monthsJournal of Molecular Histology
Myricitrin as a potent inhibitor of osteoclast differentiation via RAW264.7 Cells, BMMs and ovariectomized mouse model
Experiments in miceInterventions
Frontiers in Physiology
Mechanical signaling regulates vascular smooth muscle cell adaptation in aging
Experiments in rat cellsIntegrin signaling
European Journal of Human Genetics
Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis
Genetic association study in peopleEar
Kidney International
G-protein coupled receptor GPR124 protects against podocyte senescence and injury in diabetic kidney disease
Experiments in miceCellular senescence
Aging and Disease
Pip5k1c Loss in Chondrocytes Causes Spontaneous Osteoarthritic Lesions in Aged Mice
Experiments in miceBones and joints
Journal of the American Heart Association
Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces
Experiments in animalsInterventions
Journal of Insect Physiology
Mosquito aging modulates the heart rate and the proportional directionality of heart contractions
Experiments in model organismsMechanisms
Nature Communications
Cellular mechano-environment regulates the mammary circadian clock
Experiments in miceCircadian clock
Science Translational Medicine
Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart
Experiments in monkeysInterventions