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USF2

Gene

3 papers study it3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: National Institutes of Health and 4 more
  • Animals1
  • Cells1
  • In silico1

Effects

2

Cellular senescence

downin human cells1downin mouse cells1

2 studies

  1. USF2 inhibits cellular senescence in human cells.

    “overexpression of Usf2 led to anti-senescence effects”

    Cellshuman cardiomyocytes senescent model

    Combined Endurance and Resistance Exercise Mitigates Age-Associated Cardiac Dysfunction

    Advanced biologyMay 21, 2024

  2. USF2 inhibits cellular senescence in mouse cells.

    “Longer-term senescent cultures without USF2 mounted an exaggerated senescence regulatory program”

    Cellsin senescent cultures

    A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence

    G3 (Bethesda, Md.)Apr 25, 2023

More on Cellular senescence

DNA repair

is required forin mouse cells1

1 study

  1. USF2 is required for DNA repair in mouse cells.

    “In acute irradiation experiments, cells lacking USF2 had compromised DNA damage repair and response.”

    Cellsin acute irradiation experiments

    A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence

    G3 (Bethesda, Md.)Apr 25, 2023

More on DNA repair

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