unc-27
Gene1 paper3 findingsNCBI Gene 181124Taxon 6239
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.
- Model organisms1
Effects
3Mitochondrial fragmentation
upin worms1
1 study
Mitochondrial fragmentation
upin worms1
unc-27 increases mitochondrial fragmentation in worms.
Model organismsduring ageing; shown by disruption of UNC-27 nuclear localizationmuscle
Disrupting protein entry delays signs of muscle aging in worms · bioRxiv : the preprint server for biology · 10 Aug 2026 · Preprint
Proteostatic imbalance
upin worms1
1 study
Proteostatic imbalance
upin worms1
unc-27 increases proteostatic imbalance in worms.
Model organismsduring ageing; shown by disruption of UNC-27 nuclear localizationmuscle
Disrupting protein entry delays signs of muscle aging in worms · bioRxiv : the preprint server for biology · 10 Aug 2026 · Preprint
Sarcomeric gene expression
downin worms1
1 study
Sarcomeric gene expression
downin worms1
unc-27 decreases sarcomeric gene expression in worms.
Model organismsduring ageing; shown by disruption of UNC-27 nuclear localizationmuscle
Disrupting protein entry delays signs of muscle aging in worms · bioRxiv : the preprint server for biology · 10 Aug 2026 · Preprint
Latest
1Disrupting protein entry delays signs of muscle aging in worms
Genetic experiments in worms found that disrupting a muscle protein’s entry into cell nuclei preserved gene activity for the machinery of contraction…Genetic experiments in worms found that disrupting a muscle protein’s entry into cell nuclei preserved gene activity for the machinery of contraction during aging.