ufm-1

1. ufm-1 protects against proteotoxicity in worms.

   “ufm-1 loss exacerbated proteotoxicity in C. elegans muscle-expressed models of protein aggregation”

   Model organismsmuscle-expressed models of protein aggregation

   Exploring the organismal role of UFMylation in development, stress resilience, and neurological function in Caenorhabditis elegans

   The Journal of biological chemistry·12 Jun 2026

1. ufm-1 inhibits ER unfolded protein response in worms.

   “Loss of ufm-1 selectively activated the unfolded protein response in the ER”

   Model organismsloss of ufm-1

   Exploring the organismal role of UFMylation in development, stress resilience, and neurological function in Caenorhabditis elegans

   The Journal of biological chemistry·12 Jun 2026

More on ER unfolded protein response

1. ufm-1 improves lifespan in worms.

   “revealed that UFMylation is crucial for lifespan, development, and reproduction”

   Model organismsloss-of-function mutant

   Exploring the organismal role of UFMylation in development, stress resilience, and neurological function in Caenorhabditis elegans

   The Journal of biological chemistry·12 Jun 2026