UBE2V1
- 2 independent labs in 2 countries
- Funders: Government of Jiangsu Province and 2 more
- Animals2
Effects
6Protein aggregates
upin mice1
1 study
Protein aggregates
upin mice1
UBE2V1 increases protein aggregates in mice.
“UBE2V1 positively regulates protein aggregates formation in oocyte under both physiological and stress conditions”
Animalsunder physiological and stress conditionsoocytefemales
UBE2V1 governs aging induced protein aggregation and developmental defects in oocytes and embryos
Communications biology21 May 2025
Embryonic development
upin mice1
1 study
Embryonic development
upin mice1
UBE2V1 improves embryonic development in mice.
“partly ameliorates the age-related defects in oocyte maturation and embryo development”
Animalsin aged oocytes and embryosfemales
UBE2V1 governs aging induced protein aggregation and developmental defects in oocytes and embryos
Communications biology21 May 2025
Oocyte maturation
upin mice1
1 study
Oocyte maturation
upin mice1
UBE2V1 improves oocyte maturation in mice.
“restoring UBE2V1 expression in aged oocytes and embryos not only alleviates aggresome formation but also partly ameliorates the age-related defects in oocyte maturation”
Animalsin oocytes and embryos of advanced maternal age micefemales
UBE2V1 governs aging induced protein aggregation and developmental defects in oocytes and embryos
Communications biology21 May 2025
Cardiac function
downin mice1
1 study
Cardiac function
downin mice1
UBE2V1 impairs cardiac function in mice.
“Knocking out Ube2v1 exclusively in cardiomyocytes by using AAV9 (adeno-associated virus 9) to deliver multiplexed single guide RNAs against Ube2v1 in cardiac-specific Cas9 mice alleviated CryABR120G-induced protein aggregation, improved cardiac function, and prolonged lifespan in vivo.”
AnimalsCryABR120G-induced proteinopathyheart
Circulation research21 Feb 2020
Proteostasis
downin rat cells1
1 study
Proteostasis
downin rat cells1
UBE2V1 impairs proteostasis in rat cells.
“Overexpressing Ube2v1 promoted aggregate formation in CryABWT and CryABR120G-expressing neonatal rat ventricular cardiomyocytes.”
CellsCryABR120G expressionheart
Circulation research21 Feb 2020
Ubiquitin–proteasome system
downin rat cells1
1 study
Ubiquitin–proteasome system
downin rat cells1
UBE2V1 inhibits ubiquitin–proteasome system in rat cells.
“Ube2v1 knockdown improved ubiquitin proteasome system performance and promoted the degradation of insoluble ubiquitinated proteins in CryABR120G cardiomyocytes”
CellsCryABR120G-expressing cardiomyocytesheart
Circulation research21 Feb 2020