TMEM165
- 1 lab in 1 country
- Funders: Bureau of Frontier Sciences and Education, Chinese Academy of Sciences and 2 more
- Animals1
Effects
2Glycolysis
upin human cells1
1 study
Glycolysis
upin human cells1
TMEM165 increases glycolysis in human cells.
“whereas its depletion suppresses glycolysis, proliferation, and tumor progression.”
Cellsin glioma
Lysosomal TMEM165 remodels calcium signaling to drive hypoxia adaptation and tumor progression
Proceedings of the National Academy of Sciences of the United States of America15 Jun 2026
Lysosomal calcium storage capacity
upin human cells1
1 study
Lysosomal calcium storage capacity
upin human cells1
TMEM165 increases lysosomal calcium storage capacity in human cells.
“Under hypoxic conditions, TMEM165 expression increases, promoting calcium redistribution from the endoplasmic reticulum to lysosomes and expanding lysosomal calcium storage capacity.”
Cellsunder hypoxic conditions
Lysosomal TMEM165 remodels calcium signaling to drive hypoxia adaptation and tumor progression
Proceedings of the National Academy of Sciences of the United States of America15 Jun 2026