TK2

4 papers study it2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: Cancerfonden and 2 more

Animals4

Effects

2

Lifespan

no changein mice1

1 study

TK2 has no effect on lifespan in mice.
“Interestingly, the liver specific Tk2 KO mice had a normal life span despite a much lower mtDNA level in liver tissue.”
Animalsliver specific Tk2 KOliver
Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue
PloS oneOct 5, 2023

Total body weight

downin mice1

1 study

TK2 decreases total body weight in mice.
“A significant difference in total body weight due to the reduction of subcutaneous and visceral fat in the Dm-dNK(+/-)Tk2(-/-) mice was the only visible difference compared with control mice.”
Animalsin Dm-dNK(+/-)Tk2(-/-) mice compared with control mice
Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances
The Journal of biological chemistryOct 8, 2014

Latest

PLOS OneOct 5

Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue

Experiments in miceMechanisms

Annals of NeurologyAug 13

Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency

Experiments in miceInterventions

Human Molecular GeneticsDec 1

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome

Experiments in miceRapamycin

The Journal of Biological ChemistryOct 8

Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances

Experiments in miceInterventions