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dNK

Gene

1 paper studies it3 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Animals1

Effects

3

dNTP pools

upin mice1

1 study

  1. dNK increases dNTP pools in mice.

    “Dm-dNK expression led to increased dNTP pools and an increase in the catabolism of purine and pyrimidine nucleotides”

    Animalsin mice

    Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances

    The Journal of biological chemistry

More on dNTP pools

Mitochondrial DNA maintenance

upin mice1

1 study

  1. dNK increases mitochondrial DNA maintenance in mice.

    “The Dm-dNK(+/-)Tk2(-/-) mice maintained normal mitochondrial DNA levels throughout the observation time.”

    Animalsin Tk2(-/-) micethroughout the observation time

    Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances

    The Journal of biological chemistry

More on Mitochondrial DNA maintenance

Lifespan

upin mice1

1 study

  1. dNK extends lifespan in mice (from 3 weeks to at least 20 months).

    “transgene expression of Dm-dNK in Tk2 knock-out (Tk2(-/-)) mice extended the life span of Tk2(-/-) mice from 3 weeks to at least 20 months.”

    Animalsin Tk2 knock-out micetransgene expressionat least 20 months

    Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances

    The Journal of biological chemistry

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