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Deoxycytidine + thymidine

Deoxycytidine + thymidine has been studied in 1 paper since 2021: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Aug 13, 2021: “Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency”.

Intervention

1 paper studies it2 findingsUpdated

PubChemPubChemChEBIChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 3 more
  • Animals1

What did studies of Deoxycytidine + thymidine find?

2

Studies of Deoxycytidine + thymidine measured 2 outcomes; the most studied are mitochondrial DNA copy number (1 study) and lifespan (1).

Mitochondrial DNA copy number

upin mice1

1 study

  1. Deoxycytidine + thymidine increases mitochondrial DNA copy number in mice.

    “addition of deoxycytidine and deoxythymidine supplementation to AAV9 + AAV2 treated Tk2KI mice dramatically improved mtDNA copy numbers in the liver and kidneys”

    Animalsin AAV9 + AAV2 treated Tk2KI miceliver and kidneys

    Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency

    Annals of neurology

More on Mitochondrial DNA copy number

Lifespan

upin mice1

1 study

  1. Deoxycytidine + thymidine extends lifespan in mice.

    “Furthermore, addition of deoxycytidine and deoxythymidine supplementation to AAV9 + AAV2 treated Tk2KI mice dramatically improved mtDNA copy numbers in the liver and kidneys, animal growth, and lifespan.”

    Animalsin AAV9 + AAV2 treated Tk2KI mice

    Synergistic Deoxynucleoside and Gene Therapies for Thymidine Kinase 2 Deficiency

    Annals of neurology

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