tir-1

3 papers1 finding

NCBI Gene Taxon

1 lab in 1 country

Funder: National Natural Science Foundation of China

Model organisms3

Effects

1

NAD+

downin worms1

1 study

tir-1 decreases NAD+ in worms.
“upregulated the expression of NADase tir-1 isoform d (tir-1d)/sarm1 to decrease NAD+ level”
Model organisms
Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging
iScience7 Jan 2026

Latest

1 in 12 months

iScience2 Feb

Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging

Experiments in wormsMechanisms

Nature Communications3 Jun

Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling

Experiments in wormsGut and microbiome

bioRxiv2 Mar

Methionine cycle in a pair of serotonergic neurons regulates diet-dependent behavior and longevity through a neuron-gut signaling

Preprint: experiments in wormsSynaptic transmission