SPHK2
Gene2 papers4 findings
- Animals1
- Cells1
Effects
3Ferroptosis
upin human cells1upin mice1
1 study
Ferroptosis
upin human cells1upin mice1
SPHK2 increases ferroptosis in human cells.
Cellshematopoietic stem cells
Ferroptotic stress promotes hematopoietic stem cell aging through S1P-dependent epigenetic and lipid remodeling · Blood · 24 Aug 2026
SPHK2 increases ferroptosis in mice.
Animalshematopoietic stem cells
Ferroptotic stress promotes hematopoietic stem cell aging through S1P-dependent epigenetic and lipid remodeling · Blood · 24 Aug 2026
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
SPHK2 protects against cellular senescence in human cells.
CellsDHCR24 deficiencyendothelial cells
DHCR24 regulates endothelial senescence through the SPHK2/SPNS2-S1P axis · Biogerontology · 7 Sep 2026
HSC function
downin mice1
1 study
HSC function
downin mice1
SPHK2 impairs HSC function in mice.
Animalsaged mice
Ferroptotic stress promotes hematopoietic stem cell aging through S1P-dependent epigenetic and lipid remodeling · Blood · 24 Aug 2026