Aged HSCs
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4BloodAnimals
Fetal gene Lin28b improves ex vivo expansion of aged mouse blood stem cells
Researchers found that boosting Lin28b expression during ex vivo culture restores the transplantation and reconstitution capacity of aged mouse…Researchers found that boosting Lin28b expression during ex vivo culture restores the transplantation and reconstitution capacity of aged mouse hematopoietic stem cells.
Aging CellCells
Deep learning predicts mouse hematopoietic stem cell aging from chromatin architecture
A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified…A convolutional neural network named ChromAgeNet distinguished young from aged mouse stem cells using three-dimensional nuclear images and identified key structural markers of aging.
Signal Transduction and Targeted TherapyAnimals