SLC9A1

2 papers2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funders: National Key Research and Development Program of China and 1 more

Humans1
Cells1

Effects

1

Trophoblast invasion

upin human cells1

1 study

SLC9A1 increases trophoblast invasion in human cells.
“our findings revealed that NHE1 inhibition regulated trophoblast senescence and invasive behavior through downregulating CXCL8 and ADGRG6”
Cellsshown by NHE1 inhibitionHTR-8/SVneo
Inhibition of NHE1 induces trophoblast cell senescence via ADGRG6 mediated by CXCL8
Journal of reproductive immunology24 Jun 2026

Associations

1

Recurrent spontaneous abortion

mixedin humans1

1 study

SLC9A1 is associated with recurrent spontaneous abortion in humans.
“We found that NHE1 expression was significantly reduced in RSA villi, coinciding with impaired invasion and enhanced cell senescence.”
Humanschorionic villusfemales
Inhibition of NHE1 induces trophoblast cell senescence via ADGRG6 mediated by CXCL8
Journal of reproductive immunology24 Jun 2026

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