BNP

1. Aerobic exercise decreases BNP in humans.

   Human trialin patients with HFrEF and permanent AF12-weeks

   Biomarkers and arterial stiffness. A sub-analysis of the "Exercise training in heart failure with reduced ejection fraction and permanent atrial fibrillation: A randomized clinical trial" · Clinics (Sao Paulo, Brazil) · 10 Sep 2026

Aerobic exercise →

1. Exercise decreases BNP in humans (-18.3% (GMR 0.82; 95% CI -25.7% to -10.1%)).

   Human trialwithin 24 h after acute myocardial infarction and PCI12 weeksn = 24

   Exercise-based early cardiac rehabilitation after percutaneous coronary intervention for acute myocardial infarction : A randomized pilot trial · Wiener klinische Wochenschrift · 31 Aug 2026

Exercise →

1. SGLT2 inhibitors decrease BNP in humans (329.1 ± 78.7 vs. 514.2 ± 103.8 pmol/L).

   Humansin advanced heart failure

   SGLT2 inhibitor therapy is associated with IL-10/TGF-α/sVEGFR3 signalling and adipose tissue remodelling in advanced heart failure · Journal of molecular and cellular cardiology plus · 16 Aug 2026

SGLT2 inhibitors →

1. Dapagliflozin decreases BNP in humans (116.45 ± 12.15 vs. 214.50 ± 20.36 pg mL−1).

   Humansacute heart failure10 mg once daily6 months

   Metabolic remodeling and cardiac functional adaptation mediated by dapagliflozin in patients with acute heart failure: a retrospective cohort study · Frontiers in pharmacology · 10 Aug 2026

Dapagliflozin →