siah-1

1. Hypoxia increases siah-1 in worms.

   “Hypoxia increased Siah-1 protein levels and were associated with reduced SKN-1 transcriptional activity”

   Model organismsunder hypoxia (O2 = 1%)

   Seven in Absentia Homolog 1 Is Critical for Hypoxia-Induced Lifespan Extension in Caenorhabditis elegans by Regulating the Expression of Skinhead-1

   Gerontology·2 Apr 2026

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1. pmk-1 is required for siah-1 in worms.

   “Mechanistically, PMK-1 was required for hypoxia-induced Siah-1 upregulation and SKN-1 suppression.”

   Model organismshypoxia-induced Siah-1 upregulation and SKN-1 suppression

   Seven in Absentia Homolog 1 Is Critical for Hypoxia-Induced Lifespan Extension in Caenorhabditis elegans by Regulating the Expression of Skinhead-1

   Gerontology·2 Apr 2026

More on pmk-1