set-18

1 paper2 findings

NCBI Gene Taxon

1 lab in 1 country

Funder: National Natural Science Foundation of China

Model organisms1

Effects

2

Mitochondrial reactive oxygen species

upin model organisms1

1 study

set-18 increases mitochondrial reactive oxygen species.
“SET-18/SMYD2 were responsible for the increase of mitochondrial reactive oxygen species (mtROS) accumulation during aging”
Model organisms
Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging
iScience7 Jan 2026

More on Mitochondrial reactive oxygen species

Lifespan

downin worms1

1 study

set-18 shortens lifespan in worms.
“resulted in shortened worm lifespan”
Model organisms
Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging
iScience7 Jan 2026

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iScience2 Feb

Histone methyltransferase SET-18/SMYD2-mediated activation of NADase TIR-1d/SARM1 increases mtROS to promote aging

Experiments in wormsMechanisms