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SCN10A

Gene

3 papers study it2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 2 trials
  • Funders: Consejo Nacional de Investigaciones Científicas y Técnicas and 1 more
  • 2 of 2 trials sponsored by developers of drugs on it
  • Animals3

Interventions

1

IL-1BETA

upin rat cells1

1 study

  1. IL-1BETA increases SCN10A in rat cells.

    “in vitro IL-1β up-regulated Nav1.8 expression in DRG neurons cultured from young but not old rats.”

    Cellscultured DRG neuronsdorsal root ganglion

    Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]Mar 14, 2024

More on IL-1BETA

Effects

1

Cold sensitivity

is required forin rats1

1 study

  1. SCN10A is required for cold sensitivity in rats.

    “and of Nav1.8 and ASIC3 in cold sensitivity”

    Animalsin vivo pharmacological blockademales

    Age-dependent and modality-specific changes in the phenotypic markers Nav1.8, ASIC3, P2X3 and TRPM8 in male rat primary sensory neurons during healthy aging

    BiogerontologyDec 8, 2022

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