A-803467
A-803467 has been studied in 1 paper since 2024: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Mar 14, 2024: “Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons”.
- 2 independent labs in 2 countries
- Funders: Agencia Nacional de Promoción Científica y Tecnológica and others
- Animals1
What did studies of A-803467 find?
2Studies of A-803467 measured 2 outcomes; the most studied are mechanical allodynia (1 study) and triggered activity (1).
Mechanical allodynia
downin rats1
1 study
Mechanical allodynia
downin rats1
A-803467 decreases mechanical allodynia in rats.
“selective blockade of Nav1.8 with A803467 or of ASIC3 with APETx2 alleviated mechanical and cold allodynia and also spontaneous pain in both age groups”
Animalsinflammatory painfemales
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Triggered activity
downin mouse cells1
1 study
Triggered activity
downin mouse cells1
A-803467 inhibits triggered activity in mouse cells.
“The selective NaV1.8 blocker A-803467 (30 nM) also reduced INa,L, decreased APD and abolished triggered activity in GDX cells.”
Cellsin GDX ventricular myocytesventricular myocytes30 nMmales
American journal of physiology. Heart and circulatory physiology