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ASIC3

Gene

2 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Consejo Nacional de Investigaciones Científicas y Técnicas and 1 more
  • Animals2

Interventions

1

IL-1BETA

upin rat cells1

1 study

  1. IL-1BETA increases ASIC3 in rat cells.

    “IL-6 and IL-1β had this effect only on young and aged neurons, respectively.”

    Cellscultured DRG neurons from aged ratsdorsal root ganglion

    Complex alterations in inflammatory pain and analgesic sensitivity in young and ageing female rats: involvement of ASIC3 and Nav1.8 in primary sensory neurons

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]

More on IL-1BETA

Effects

1

Mechanosensation

is required forin rats1

1 study

  1. ASIC3 is required for mechanosensation in rats.

    “demonstrated the involvement of ASIC3 and P2X3 in normal mechanosensation”

    Animalsin vivo pharmacological blockademales

    Age-dependent and modality-specific changes in the phenotypic markers Nav1.8, ASIC3, P2X3 and TRPM8 in male rat primary sensory neurons during healthy aging

    Biogerontology

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