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Rt-sirtuin2

Gene

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Cells1

Effects

3

Ageing indexes

upin animals1

1 study

  1. Rt-sirtuin2 improves ageing indexes.

    “In vivo experiments with animals also confirmed the improvement of various ageing indexes by the Rt-sirtuin2 and Rt-sirtuin4 genes.”

    Animalsin vivo

    Rhodosporidium toruloides sir2-like genes remodelled the mitochondrial network to improve the phenotypes of ageing cells

    Free radical biology & medicine30 Dec 2018

Mitochondrial function

upin cells1

1 study

  1. Rt-sirtuin2 improves mitochondrial function in cells.

    “they can significantly improve cellular responses to H2O2 treatment, which induces cell senescence, and restore mitochondrial function”

    CellsH2O2 treatment

    Rhodosporidium toruloides sir2-like genes remodelled the mitochondrial network to improve the phenotypes of ageing cells

    Free radical biology & medicine30 Dec 2018

Lifespan

upin R. toruloides cells1

1 study

  1. Rt-sirtuin2 extends lifespan in R. toruloides cells.

    “Rt-sirtuin2 and Rt-sirtuin4 genes transfections significantly impacted the lifespan of Rhodosporidium toruloides”

    Cellsgene transfection

    Rhodosporidium toruloides sir2-like genes remodelled the mitochondrial network to improve the phenotypes of ageing cells

    Free radical biology & medicine30 Dec 2018

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