RSL1D1

1. RSL1D1 increases FTH1 in human cells.

   “RSL1D1 overexpression enhanced this interaction, thereby stabilizing FTH1 mRNA expression.”

   Cellshigh glucose exposureretinal pigment epithelium

   RSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy

   Biochimica et biophysica acta. Molecular cell research·Jul 21, 2026

More on FTH1

1. RSL1D1 protects against ferroptosis in human cells.

   “Downregulation of RSL1D1 led to RPE cell senescence and dysregulated iron homeostasis-induced ferroptosis.”

   Cellsdownregulation of RSL1D1retinal pigment epithelium

   RSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy

   Biochimica et biophysica acta. Molecular cell research·Jul 21, 2026

More on Ferroptosis

1. RSL1D1 protects against cellular senescence in human cells.

   “Downregulation of RSL1D1 led to RPE cell senescence and dysregulated iron homeostasis-induced ferroptosis.”

   Cellsdownregulation of RSL1D1retinal pigment epithelium

   RSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy

   Biochimica et biophysica acta. Molecular cell research·Jul 21, 2026

More on Cellular senescence

1. RSL1D1 increases PPARγ mRNA stability in mouse cells.

   “RSL1D1 directly interacts with the 3'-untranslated region of PPARγ mRNA, and then promotes its stability”

   CellsHuR-dependent manner

   RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability

   Life sciences·Aug 5, 2022

1. RSL1D1 induces hepatic damage in mice.

   “RSL1D1 knockout in mouse adipose tissue shortens mouse lifespan and leads to hepatic damage”

   Animalsadipose tissue knockoutliver

   RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability

   Life sciences·Aug 5, 2022

1. RSL1D1 shortens lifespan in mice.

   “RSL1D1 knockout in mouse adipose tissue shortens mouse lifespan”

   Animalsadipose tissue knockoutadipose tissue

   RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability

   Life sciences·Aug 5, 2022

1. Diabetic retinopathy decreases RSL1D1 in mice.

   “RSL1D1 and FTH1 expression were significantly reduced in the RPE layer of diabetic mice and HG-induced ARPE-19 cells.”

   Animalsin RPE layer of diabetic mice and HG-induced ARPE-19 cells

   RSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy

   Biochimica et biophysica acta. Molecular cell research·Jul 21, 2026

More on Diabetic retinopathy