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RNH1

Gene

2 papers study it3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Deutsche Forschungsgemeinschaft and 3 more
  • Model organisms1
  • Cells1

Effects

3

RAD51

is required forin yeast cells1

1 study

  1. RNH1 is required for RAD51 in yeast cells.

    “The recruitment of RNase H1 is essential to allow for the loading of Rad51”

    Cellsat short telomeres

    RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres

    EMBO reports

More on RAD51

Cellular senescence

downin yeast cells1

1 study

  1. RNH1 prevents cellular senescence in yeast cells.

    “In the absence of RNase H1 or Sen1 function, yeast cultures prematurely enter replicative senescence in the absence of telomerase.”

    Cellsin the absence of telomerase

    RNase H1 and Sen1 ensure that transient TERRA R-loops promote the repair of short telomeres

    EMBO reports

More on Cellular senescence

Positive light response

upin flies1

1 study

  1. RNH1 improves positive light response in flies.

    “over-expression of Top3β or nuclear-localized RNase H1, which resolves R-loops, enhanced positive light response during aging”

    Model organismsover-expression of nuclear-localized RNase H1photoreceptors

    Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during aging

    Aging cell

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