TOP3B

1. TOP3B shortens lifespan in mice.

   “In addition, the findings that it can facilitate autophagy may account for the shortened lifespan of Top3b-KO mice.”

   ReviewTop3b-KO

   A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation

   Nucleic acids research·Mar 21, 2023

2. TOP3B extends lifespan in mice (about 15 months vs >2 years).

   “Mice lacking DNA topoisomerase IIIbeta have a shorter life expectancy than their wild-type littermates, however. The mean lifespan of the top3beta(-/-) mice is about 15 months, whereas that of their wild-type littermates is longer than 2 years.”

   Animalsshown by knockout

   Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan

   Proceedings of the National Academy of Sciences of the United States of America·May 1, 2001

1. TOP3B activates autophagy in human cells.

   “Furthermore, TOP3B-ablated cells display reduced transcription of several autophagy-associated genes and autophagy per se.”

   Cellsstarvation

   A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation

   Nucleic acids research·Mar 21, 2023

More on Autophagy

1. TOP3B has no effect on T lymphocyte activation in mice.

   “revealed no significant aberrations in their central and peripheral tolerance or in T lymphocyte activation”

   Animalsin top3beta(-/-) mice

   Development of autoimmunity in mice lacking DNA topoisomerase 3beta

   Proceedings of the National Academy of Sciences of the United States of America·May 21, 2007

1. TOP3B decreases apoptosis in mice.

   “as well as an increase in apoptotic cells in the thymus”

   Animalsshown by knockoutthymus

   Development of autoimmunity in mice lacking DNA topoisomerase 3beta

   Proceedings of the National Academy of Sciences of the United States of America·May 21, 2007

More on Apoptosis

1. TOP3B decreases chromosomal aberrations in mice.

   “The mutant mice also show an increase in numerical aberrations of chromosomes in splenocytes and bone marrow cells”

   Animalsshown by knockoutspleen, bone marrow

   Development of autoimmunity in mice lacking DNA topoisomerase 3beta

   Proceedings of the National Academy of Sciences of the United States of America·May 21, 2007