There are 2 papers on RIG-I in aging research: none in people yet, 2 in animals.
At a glance
The findings reach cells, none yet in people. 2 independent labs in 1 country.
None of its findings points the other way.
Cells: a single group. Worms or flies, mice and humans: nothing yet.
- 2 independent labs in 1 country
- Funder: National Natural Science Foundation of China
- Animals2
Interventions
1Flavin adenine dinucleotide
downin mouse cells1
1 study
Flavin adenine dinucleotide
downin mouse cells1
Flavin adenine dinucleotide inhibits RIG-I in mouse cells.
“It bound directly to cytosolic nucleic acid sensors cyclic GMP-AMP synthase (cGAS) and retinoic acid-inducible gene I (RIG-I), occupying catalytic pockets to suppress their activity”
Cells
Immunity
Effects
1Integrin β3
downin mouse cells1
1 study
Integrin β3
downin mouse cells1
RIG-I decreases integrin β3 in mouse cells.
“integrin β3 was negatively regulated by Rig-I, and significantly upregulated with the occurrence of senescence.”
Cells
Cell cycle (Georgetown, Tex.)