psme-3

psme-3 decreases protein aggregation in worms.

“cold-induced PA28γ/PSME-3 diminishes protein aggregation in C. elegans models of age-related diseases such as Huntington's and amyotrophic lateral sclerosis.”

Model organismscold exposure in Huntington's disease and amyotrophic lateral sclerosis models

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

Nature aging·3 Apr 2023

psme-3 improves protein degradation in worms.

“This proteasome activator is required for cold-induced longevity and ameliorates age-related deficits in protein degradation.”

Model organismsage-related deficits

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

Nature aging·3 Apr 2023

psme-3 is required for lifespan in worms.

“This proteasome activator is required for cold-induced longevity”

Model organismscold-induced longevity15 °C

Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes

Nature aging·3 Apr 2023