PRKAR2B

1. PRKAR2B extends lifespan in mice.

   “C57/BL6J male mice lacking the regulatory RIIbeta subunit have extended lifespan”

   Reviewlacking the regulatory RIIbeta subunitmales

   Protein kinase A is a target for aging and the aging heart

   Aging·1 Apr 2010

2. PRKAR2B extends lifespan in mice (from 884 days to 1005 days).

   “The median lifespan was increased from 884 days to 1005 days (p = 0.006 as determined by the log rank test)”

   AnimalsRIIbeta(-/-) vs WTmales

   Disruption of protein kinase A in mice enhances healthy aging

   PloS one·18 Jun 2009

1. PRKAR2B prevents fatty liver disease in mice.

   “Male mutants were also resistant to age-induced fatty liver.”

   AnimalsRIIbeta(-/-) vs WTmales

   Disruption of protein kinase A in mice enhances healthy aging

   PloS one·18 Jun 2009

More on Fatty liver disease

1. PRKAR2B decreases kidney disease in mice.

   “decreased severity of renal lesions, and a trend towards a decrease in age-related cardiac pathology.”

   AnimalsRIIbeta(-/-) vs WTmales

   Disruption of protein kinase A in mice enhances healthy aging

   PloS one·18 Jun 2009

More on Kidney disease

1. PRKAR2B lowers the risk of neoplasm in mice.

   “Pathological assessment of tissues from end of life male mutant mice showed a decrease in tumor incidence”

   AnimalsRIIbeta(-/-) vs WTmales

   Disruption of protein kinase A in mice enhances healthy aging

   PloS one·18 Jun 2009

More on Neoplasm