PPP6R3

Gene

2 papers3 findings

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 1 more
  • Animals1
  • In silico1

Effects

3

Cellular senescence

upin mice1

1 study
  1. PPP6R3 induces cellular senescence in mice.

    “Deletion of SAPS3 leads to AMPK activation and reverses cellular senescence”

    Animalsshown by deletion

    The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism

    Science advances24 Oct 2025

More on Cellular senescence

AMPK signalling

downin mice1

1 study
  1. PPP6R3 inhibits AMPK signalling in mice.

    “SAPS3 expression is increased during aging to inhibit adenosine monophosphate-activated kinase (AMPK) activity.”

    Animals

    The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism

    Science advances24 Oct 2025

More on AMPK signalling

Physical function

downin mice1

1 study
  1. PPP6R3 impairs physical function in mice.

    “SAPS3 deficiency improves the effects of aging on the affective behaviors, cognition, and motor functions in aged mice.”

    Animalsshown by deficiency

    The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism

    Science advances24 Oct 2025

Latest

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