PPP6R3
2 papers3 findings
- 1 lab in 1 country
- Funders: National Cancer Institute and 1 more
- Animals1
- In silico1
Effects
3Cellular senescence
upin mice1
1 study
Cellular senescence
upin mice1
PPP6R3 induces cellular senescence in mice.
“Deletion of SAPS3 leads to AMPK activation and reverses cellular senescence”
Animalsshown by deletion
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
Science advances24 Oct 2025
AMPK signalling
downin mice1
1 study
AMPK signalling
downin mice1
PPP6R3 inhibits AMPK signalling in mice.
“SAPS3 expression is increased during aging to inhibit adenosine monophosphate-activated kinase (AMPK) activity.”
Animals
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
Science advances24 Oct 2025
Physical function
downin mice1
1 study
Physical function
downin mice1
PPP6R3 impairs physical function in mice.
“SAPS3 deficiency improves the effects of aging on the affective behaviors, cognition, and motor functions in aged mice.”
Animalsshown by deficiency
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
Science advances24 Oct 2025
Latest
1 in 12 monthsJournal of Translational Medicine
Genomic structural equation modeling decodes skeletal aging: novel loci discovery and multisystem genetic crosstalk
Computational studyBiomarkers
Science Advances
The protein phosphatase 6 subunit SAPS3 modulates lifespan by regulating metabolism
Experiments in miceLipid and ceramide metabolism