POC5
- 1 lab in 1 country
- Funders: Agence Nationale de la Recherche and 1 more
- Humans1
Effects
3Adipogenesis
is required forin human cells1
1 study
Adipogenesis
is required forin human cells1
POC5 is required for adipogenesis in human cells.
“These phenotypes were recapitulated in POC5-KO ASCs, which additionally exhibited a near complete block of adipogenic differentiation”
Cellsshown by POC5-KO ASCs
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyJul 27, 2026
Cellular senescence
downin human cells1
1 study
Cellular senescence
downin human cells1
POC5 prevents cellular senescence in human cells.
“Overall, POC5 deficiency promotes insulin resistance and premature senescence, and impaired adipogenesis.”
Cellsshown by POC5 deficiency/knockout
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyJul 27, 2026
Cell proliferation
downin human cells1−35%
1 study
Cell proliferation
downin human cells1−35%
POC5 decreases cell proliferation in human cells (-35%).
“These defects were associated with a 35% decrease in proliferation and a premature senescence”
CellsPOC5-deficient fibroblasts
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyJul 27, 2026