PMCH

2 papers2 findings

HGNC NCBI Gene Taxon

1 lab in 1 country

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Animals2

Effects

2

Insulin resistance

upin mice1

1 study

PMCH increases insulin resistance in mice.
“Aged MCH(-/-) mice exhibited better glucose tolerance and were more insulin sensitive compared with wild-type controls.”
Animalsaging
MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance
Diabetes1 Feb 2006

More on Insulin resistance

Body weight

downin mice1

1 study

PMCH decreases body weight in mice (-23.4% (male), -30.8% (female)).
“At 19 months, MCH(-/-) male and female mice weighed 23.4 and 30.8% less than their wild-type counterparts”
Animalsaging
MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance
Diabetes1 Feb 2006

Latest

Diabetes1 Feb

MCH-/- mice are resistant to aging-associated increases in body weight and insulin resistance

Experiments in miceMechanisms

Journal of Neuroendocrinology1 Dec

Plasma and hypothalamic peptide-hormone levels regulating somatotroph function and energy balance in fed and fasted states: a comparative study in four strains of rats

Experiments in ratsMechanisms