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PIWIL2

Gene

3 papers3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Associazione Italiana per la Ricerca sul Cancro and 5 more
  • Animals3

Effects

3

Reactive glia

downin mice1

1 study

  1. PIWIL2 inhibits reactive glia in mice.

    “Depletion of Mili and piRNAs in the adult hippocampus impairs aNPC differentiation toward a neural fate, induces senescence, and generates reactive glia.”

    AnimalsMili and piRNA depletionadult hippocampus

    Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus

    EMBO reportsDec 6, 2022

Cellular senescence

downin mice1

1 study

  1. PIWIL2 prevents cellular senescence in mice.

    “Depletion of Mili and piRNAs in the adult hippocampus impairs aNPC differentiation toward a neural fate, induces senescence, and generates reactive glia.”

    AnimalsMili and piRNA depletionadult hippocampus

    Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus

    EMBO reportsDec 6, 2022

More on Cellular senescence

Stem cell differentiation

is required forin mice1

1 study

  1. PIWIL2 is required for stem cell differentiation in mice.

    “Depletion of Mili and piRNAs in the adult hippocampus impairs aNPC differentiation toward a neural fate, induces senescence, and generates reactive glia.”

    AnimalsMili and piRNA depletionadult hippocampus

    Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus

    EMBO reportsDec 6, 2022

More on Stem cell differentiation

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