PIN1
- 1 lab in 1 country
- Funders: Purdue University and 1 more
- Animals1
- Cells1
Effects
2Cell cycle regulation
downin human cells1
1 study
Cell cycle regulation
downin human cells1
PIN1 decreases cell cycle regulation in human cells.
“PIN1 knockdown promotes cell proliferation, while diminishing the senescence phenotype”
Cellsin response to oncogenic RASG12V activation
Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence
Molecular & cellular proteomics : MCP10 Jan 2024
Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
PIN1 increases cellular senescence in human cells.
“PIN1 knockdown promotes cell proliferation, while diminishing the senescence phenotype and hallmarks of senescence, including p21, p16, and p53”
Cellsin response to oncogenic RASG12V activation
Nuclear Phosphoproteome Reveals Prolyl Isomerase PIN1 as a Modulator of Oncogene-Induced Senescence
Molecular & cellular proteomics : MCP10 Jan 2024
Funding
4 grants since 2017Japan Society for the Promotion of ScienceJP¥41.5m
The contribution of Pin1 on thamamic regulation and age-related neurodegenerative diseases
Japan Society for the Promotion of ScienceSHOWA Medical University HospitalJP¥14.7m2024–2026
Role of Pin1 in the muscle function and metabolic regulation
Japan Society for the Promotion of ScienceHiroshima UniversityJP¥17.8m2020–2023
The regulation of excise and energy metabolism by Pin1 in skeletal muscle
Japan Society for the Promotion of ScienceHiroshima UniversityJP¥4.3m2019–2023
A new approach for avoiding age-related risks after extended hepatectomy by targeting Pin1.
Japan Society for the Promotion of ScienceChiba UniversityJP¥4.7m2017–2020