PAQR4

1. Ovariectomy decreases PAQR4.

   “Experimental validation confirmed decreased PAQR4 expression in both bone and muscle tissues of the DSO model.”

   Animalsin DSO model (bilateral ovariectomy with natural aging)bone and muscle

   Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation

   Experimental gerontology·12 Jan 2026

More on Ovariectomy

1. PAQR4 increases metastasis in human cells.

   “The knockdown of PAQR4 significantly inhibited the proliferation and metastasis of BLCA cells.”

   Cellsshown by knockdown

   PAQR4: A Critical Senescence-Related Gene Influencing Immune Evasion and Metastasis in Bladder Urothelial Carcinoma

   Human mutation·12 Sep 2025

1. PAQR4 increases proliferation in human cells.

   “The knockdown of PAQR4 significantly inhibited the proliferation and metastasis of BLCA cells.”

   Cellsshown by knockdown

   PAQR4: A Critical Senescence-Related Gene Influencing Immune Evasion and Metastasis in Bladder Urothelial Carcinoma

   Human mutation·12 Sep 2025

1. Osteosarcopenia is associated with PAQR4 in silico.

   “Among them, PAQR4 showed the highest predictive value in ROC analysis and was consistently downregulated in both training and validation datasets.”

   In silicoin osteosarcopenia datasets

   Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation

   Experimental gerontology·12 Jan 2026

More on Osteosarcopenia

1. PAQR4 is associated with survival in silico.

   “Notably, PAQR4 was identified as a critical aging-related gene linked to poor prognosis and an immunosuppressive microenvironment.”

   In silico

   PAQR4: A Critical Senescence-Related Gene Influencing Immune Evasion and Metastasis in Bladder Urothelial Carcinoma

   Human mutation·12 Sep 2025