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PADI2

Gene

4 papers study it2 findings

HGNCMGINCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • 1 trial
  • Funders: National Institute of General Medical Sciences and 1 more
  • 1 of 1 trial sponsored by developers of drugs on it
  • Animals2
  • Cells2

Interventions

1

Estradiol

no changein mice1

1 study

  1. Estradiol has no effect on PADI2 in mice.

    “Contrary to our hypothesis, PAD2 expression was not regulated by E2 in the heart.”

    Animalsheart

    Cardiac PAD2 expression and myocardial citrullination decline with age in female mice independent of estrogen

    American journal of physiology. Heart and circulatory physiologyJun 3, 2025

More on Estradiol

Effects

1

Diastolic dysfunction

downin mice1

1 study

  1. PADI2 protects against diastolic dysfunction in mice.

    “loss of PAD2 resulted in diastolic dysfunction.”

    Animalsshown by knockoutheartfemales

    Cardiac PAD2 expression and myocardial citrullination decline with age in female mice independent of estrogen

    American journal of physiology. Heart and circulatory physiologyJun 3, 2025

More on Diastolic dysfunction

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