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P90RSK

There is 1 paper on P90RSK in aging research: 1 observational study in people.

Gene

1 paper studies it2 findings

HGNCNCBI GeneTaxon

See all 1 papers on P90RSK

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: American Heart Association and others
  • Humans1

Effects

2

Atherosclerosis

upin mice1

1 study

  1. P90RSK increases atherosclerosis in mice (myeloid-specific dominant-negative p90RSK transgenic versus wild-type mice).

    “the data obtained from our gain- or loss-of-function mice conclusively showed the crucial role of p90RSK in inducing senescent phenotype in macrophages and atherogenesis.”

    Animalsmyeloid-specific dominant-negative p90RSK transgenic versus wild-type mice

    Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals

    Circulation

More on Atherosclerosis

Cellular senescence

upin mice1

1 study

  1. P90RSK increases cellular senescence in mice (myeloid-specific dominant-negative p90RSK transgenic versus wild-type mice).

    “the data obtained from our gain- or loss-of-function mice conclusively showed the crucial role of p90RSK in inducing senescent phenotype in macrophages and atherogenesis.”

    Animalsmyeloid-specific dominant-negative p90RSK transgenic versus wild-type micemacrophage

    Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV-Positive Individuals

    Circulation

More on Cellular senescence

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