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MVP

Gene

2 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Government of Jiangsu Province and 2 more
  • Animals2

Effects

2

Osteoporosis

downin mice1

1 study

  1. MVP protects against osteoporosis in mice.

    “Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts”

    Animalsin aging and estrogen deficiency contexts

    Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts

    Cell death & diseaseSep 13, 2023

More on Osteoporosis

Apoptosis

upin mice1

1 study

  1. MVP induces apoptosis in mice.

    “conditional knockout of MVP inhibited osteoclast apoptosis in vivo and in vitro.”

    Animalsconditional knockout in monocyte lineage (Mvpf/fLyz2-Cre)bone

    Major vault protein (MVP) suppresses aging- and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts

    Cell death & diseaseSep 13, 2023

More on Apoptosis

Funding

1 grant since 2019

Veterans Affairs

Latest

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