There are 3 papers on MURF1 in aging research: 1 trial in people, 2 in animals.
At a glance
The findings reach people, from one lab or study. 3 independent labs in 3 countries.
None of its findings points the other way.
- 3 independent labs in 3 countries
- Funders: China Postdoctoral Science Foundation and others
- Human trial1
- Animals2
Interventions
3Resistance training
downin mice1
1 study
Resistance training
downin mice1
Resistance training decreases MURF1 in T2DM mice; MAFbx/Atrogin-1 measured alongside.
“suppressing the expression of the atrophy-related E3 ubiquitin ligases MuRF1 and MAFbx/Atrogin-1”
Animalsin T2DM mice; MAFbx/Atrogin-1 measured alongsideskeletal muscle8 weeks
Biomolecules
Blood-flow-restricted exercise
upin humans1
1 study
Blood-flow-restricted exercise
upin humans1
Blood-flow-restricted exercise increases MURF1 in humans (healthy controls, BFRE-trained versus untrained vastus lateralis) (1.34 ± 0.31-fold difference).
“In controls, satellite cell content and MuRF1 transcript expression were significantly higher (1.53 ± 0.30- and 1.34 ± 0.31-fold difference, respectively)”
Human trialhealthy controls, BFRE-trained versus untrained vastus lateralisvastus lateraliseight sets of eight knee extensions at 30% isometric peak torquefive consecutive daily sessionsn = 8
Frontiers in physiology
Panax ginseng
downin mice1
1 study
Panax ginseng
downin mice1
Panax ginseng decreases MURF1 in mice (old mice).
“reducing degradation proteins FoxO3a, MuRF1, and Fbx32”
Animalsold micefermented red ginseng extractskeletal muscle50-200 mg/kg/daysix weeks
Food science and biotechnology