There are 7 papers on MT-TL1 in aging research: 1 trial and 2 observational studies in people, 2 in animals, 1 in cells, 1 review.
At a glance
The findings reach cells, none yet in people. 1 lab in 1 country.
Cells: a single group. Worms or flies, mice and humans: nothing yet.
- 1 lab in 1 country
- Funders: Beijing Municipal Science and Technology Commission and 1 more
- Human trial1
- Humans2
- Animals2
- Cells1
Effects
1Complex I enzymatic activity
downin human cells1
1 study
Complex I enzymatic activity
downin human cells1
MT-TL1 impairs complex I enzymatic activity in human cells (m.3243 A>G mutation, patient fibroblasts vs controls) (significant reduction).
“M.3243 A>G fibroblasts showed a significant reduction in complex I core subunit 6, complex I enzymatic activity”
Cellsm.3243 A>G mutation, patient fibroblasts vs controlsfibroblast
Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation
Frontiers in physiology
Latest
1 paper in 12 monthsCell Reports
A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs
Experiments in animalsInterventions
Nature Communications
Selfish mutations promote age-associated erosion of mtDNA integrity in mammals
Study in peopleMechanisms
Frontiers in Physiology
Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation
Experiments in human cellsInterventions
medRxiv
T cell differentiation drives the negative selection of pathogenic mtDNA variants
Preprint: cohort study of 26 peopleStem cell differentiation
Journal of Neurology, Neurosurgery, and Psychiatry
Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial
Non-randomized trial in 10 peopleTaurine
Advances in Experimental Medicine and Biology
Taurine deficiency and MELAS are closely related syndromes
ReviewMechanisms