Papers on MT-TL1

7 papers

Thursday, February 12

Cell ReportsFeb 12

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs

Experiments in animalsInterventions

Wednesday, July 2

Nature CommunicationsJul 2

Selfish mutations promote age-associated erosion of mtDNA integrity in mammals

Study in peopleMechanisms

Saturday, March 9

Cell MetabolismMar 9

Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Experiments in miceMitochondrial translation

Tuesday, August 15

Frontiers in PhysiologyAug 15

Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation

Experiments in human cellsInterventions

Friday, April 28

medRxivApr 28

T cell differentiation drives the negative selection of pathogenic mtDNA variants

Preprint: cohort study of 26 peopleStem cell differentiation

Tuesday, April 17

Journal of Neurology, Neurosurgery, and PsychiatryApr 17

Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial

Non-randomized trial in 10 peopleTaurine

Tuesday, January 1

Advances in Experimental Medicine and BiologyJan 1

Taurine deficiency and MELAS are closely related syndromes

ReviewMechanisms