Complex I enzymatic activity

There is 1 paper on complex I enzymatic activity in aging research: none in people yet, 1 in cells. The newest story, Nov 1, 2026: “Cell energy systems change in aging mouse brain nerve endings”.

Biomarker

1 paper studies it4 more mention it1 finding

See all 5 papers on complex I enzymatic activity

  • Cells1

Upstream

1

MT-TL1

downin human cells1

1 study
  1. MT-TL1 impairs complex I enzymatic activity in human cells (m.3243 A>G mutation, patient fibroblasts vs controls) (significant reduction).

    “M.3243 A>G fibroblasts showed a significant reduction in complex I core subunit 6, complex I enzymatic activity”

    Cellsm.3243 A>G mutation, patient fibroblasts vs controlsfibroblast

    Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation

    Frontiers in physiology

More on MT-TL1

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 1May 2026: 1Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 02 papers in 12 months
Journal of Bioenergetics and Biomembranes

Cell energy systems change in aging mouse brain nerve endings

The voltage across mitochondrial membranes fell 21% at 20 months but rose 24% at 24 months, compared with young mice.The voltage across mitochondrial membranes fell 21% at 20 months but rose 24% at 24 months, compared with young mice.

Mouse studyMechanisms