Mitochondrial diseases
- Animals1
- Cells1
Effects
2Lifespan
downin humans1
1 study
Lifespan
downin humans1
Mitochondrial diseases shorten lifespan in humans.
“Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with fatigue and multi-system disorders, are often lean, and die prematurely”
Review
Communications biology12 Jan 2023
Resting energy expenditure
upin humans1
1 study
Resting energy expenditure
upin humans1
Mitochondrial diseases increase resting energy expenditure in humans.
“these disorders increase resting energy expenditure, a state termed hypermetabolism.”
Humansin patients with mitochondrial diseasesn = 690
Communications biology12 Jan 2023
Associations
1GDF-15
upin humans1
1 study
GDF-15
upin humans1
GDF-15 predicts mitochondrial diseases in humans.
“growth differentiation factor 15 (GDF15) is a useful diagnostic marker for mitochondrial diseases”
Review
Geriatrics & gerontology international1 Mar 2016
Trial sponsors
Company4 trialsPhase 3278 people
Company1 trialPhase 3102 people
Company1 trialPhase 160 people
Company1 trialPhase 114 people
University of Kansas Medical Center
1 trialPhase 468 people
1 trialPhase 324 people
Woodinville Psychiatric Associates
1 trialPhase 261 people
Children's Hospital of Philadelphia
1 trialPhase 170 people
Latest
2 in 12 monthsJournal of Translational Medicine
Impaired NADH-linked mitochondrial respiration disrupts ventral midbrain neuronal programs in POLG disease
Experiments in human cellsInterventions
Nature Metabolism
Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome
Experiments in miceInterventions
Communications Biology
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Experiments in human cellsOxidative phosphorylation
Geriatrics & Gerontology International
Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders
ReviewBiomarkers