MSLN

1. MSLN induces cellular senescence in mice.

   “Ductular proliferation and hepatocyte and cholangiocyte senescence were suppressed in Mdr2-/-Msln-/- and Mdr2-/-Muc16-/- mice”

   Animalsin Mdr2-/- miceliver

   Mesothelin/Mucin 16 Signaling in Activated Portal Fibroblasts Drives the Development of Cholestatic Fibrosis and Hepatocellular Carcinoma in Aged Female Multidrug Resistance Protein 2 Knockout Mice

   Cellular and molecular gastroenterology and hepatology·Apr 11, 2026

2. MSLN inhibits cellular senescence in cells.

   “MSLN-deficient cells exhibited classic senescence features-growth arrest, an enlarged morphology, and elevated SA-β-gal activity.”

   CellsMSLN-deficient PDAC cells

   Mesothelin-Associated Anti-Senescence Through P53 in Pancreatic Ductal Adenocarcinoma

   Cancers·Jun 19, 2025

More on Cellular senescence

1. MSLN increases cholestatic fibrosis in mice.

   “Deletion of Msln or Muc16 ameliorated cholestatic fibrosis, inflammation and HCC in Mdr2-/-Msln-/- and Mdr2-/-Muc16-/- mice”

   Animalsin Mdr2-/- miceliver

   Mesothelin/Mucin 16 Signaling in Activated Portal Fibroblasts Drives the Development of Cholestatic Fibrosis and Hepatocellular Carcinoma in Aged Female Multidrug Resistance Protein 2 Knockout Mice

   Cellular and molecular gastroenterology and hepatology·Apr 11, 2026

More on Cholestatic fibrosis

1. MSLN inhibits DNA damage response in cells.

   “increased γH2AX levels, indicating the activation of the DNA damage response.”

   CellsMSLN-deficient PDAC cells

   Mesothelin-Associated Anti-Senescence Through P53 in Pancreatic Ductal Adenocarcinoma

   Cancers·Jun 19, 2025

More on DNA damage response