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MPG

Gene

2 papers1 finding

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology and 3 more
  • Animals2

Effects

1

Lifespan

upin mice1

1 study

  1. MPG extends lifespan in mice.

    “repair of spontaneous DNA damage by alkyladenine DNA glycosylase (Aag/Mpg)-initiated base excision repair and O(6)-methylguanine DNA methyltransferase (Mgmt)-mediated direct reversal contributes to maximum life span”

    Animalsin mice

    Repair of endogenous DNA base lesions modulate lifespan in mice

    DNA repair30 Jun 2014

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